{"id":99,"date":"2018-11-14T20:57:26","date_gmt":"2018-11-14T20:57:26","guid":{"rendered":"http:\/\/crcmoonshot.org\/?page_id=99"},"modified":"2018-11-14T21:15:40","modified_gmt":"2018-11-14T21:15:40","slug":"pathdrive","status":"publish","type":"page","link":"https:\/\/crcmoonshot.org\/?page_id=99","title":{"rendered":"pathDrive"},"content":{"rendered":"<p><strong>pathDrive<\/strong> is a novel methodology developed by a team lead by Jeff Morris as part of the Moon Shot.\u00a0 It is available on the internal development server and therefore not considered stable.\u00a0 Click the icon below to access.\u00a0 Please note it is only accessible from within MD Anderson.\u00a0 Contact Dr. Morris (<a href=\"mailto:jefmorris@mdanderson.org\">jefmorris@mdanderson.org<\/a>) if the server is down.<\/p>\n<p><a href=\"http:\/\/qcprpudev6.mdanderson.edu:3833\/pathDrive_YZhang\/\"><img loading=\"lazy\" class=\"alignnone size-full wp-image-50\" src=\"http:\/\/crcmoonshot.org\/wp-content\/uploads\/secure-access-1.jpeg\" alt=\"\" width=\"372\" height=\"135\" srcset=\"https:\/\/crcmoonshot.org\/wp-content\/uploads\/secure-access-1.jpeg 372w, https:\/\/crcmoonshot.org\/wp-content\/uploads\/secure-access-1-300x109.jpeg 300w\" sizes=\"(max-width: 372px) 100vw, 372px\" \/><\/a><\/p>\n<p><strong>Rationale for pathDRIVE:<\/strong><\/p>\n<p>The vastness of multi-platform molecular data raises many challenges<\/p>\n<ul>\n<li>DNA\/epigenetic measurements relatively easy to measure and often targetable but not functional<\/li>\n<li>mRNA\/proteins closer to functional but not targetable<\/li>\n<li>Individual genes difficult to interpret functionally given complex pathways<\/li>\n<li>Pathway scores summarize activity across genes, are pseudo-functional<\/li>\n<\/ul>\n<p>In response to these challenges, our goal is to devise a method to identify sparse sets of upstream effectors explaining a high level of variability in pathway scores<\/p>\n<ul>\n<li>Find key \u201cleverage points\u201d within the pathways.<\/li>\n<li>We will apply this method to key pathways characterizing CRC subtypes to identify potential subtype-specific targets.<\/li>\n<\/ul>\n<p><span style=\"color: #ff0000;\">For more information, please see <a style=\"color: #ff0000;\" href=\"https:\/\/myteams.mdanderson.org\/depts\/gimo\/CMS400\/Shared%20Documents\/CRC%20Moon%20Shot\/pathDRIVE%20and%20CMS.pptx?Web=1\"><span style=\"color: #3366ff;\">this pathDRIVE PowerPoint presentation<\/span>.<\/a> <\/span><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>pathDrive is a novel methodology developed by a team lead by Jeff Morris as part of the Moon Shot.\u00a0 It is available on the internal development server and therefore not considered stable.\u00a0 Click the icon below to access.\u00a0 Please note it is only accessible from within MD Anderson.\u00a0 Contact Dr. Morris (jefmorris@mdanderson.org) if the server &hellip; <a href=\"https:\/\/crcmoonshot.org\/?page_id=99\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">pathDrive<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/crcmoonshot.org\/index.php?rest_route=\/wp\/v2\/pages\/99"}],"collection":[{"href":"https:\/\/crcmoonshot.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/crcmoonshot.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/crcmoonshot.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/crcmoonshot.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=99"}],"version-history":[{"count":3,"href":"https:\/\/crcmoonshot.org\/index.php?rest_route=\/wp\/v2\/pages\/99\/revisions"}],"predecessor-version":[{"id":112,"href":"https:\/\/crcmoonshot.org\/index.php?rest_route=\/wp\/v2\/pages\/99\/revisions\/112"}],"wp:attachment":[{"href":"https:\/\/crcmoonshot.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=99"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}